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| Publications (1999- ) |
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Stressor Effects: Neurochemical and Behavioral sequelae |
| Anisman, H., & Merali, Z. Learned helplessness in mice. 2009. In T. Gould (Ed). Mood and Anxiety Related Phenotypes in Mice.. Humana Press, Totowa, NJ, in press. |
| Wann, P.B., Audet, M-C., Gibb, J., & Anisman, H. (2009). Anhedonia and altered cardiac atrial natriuretic peptide following chronic stressor and endotoxin treatment in mice. Psychoneuroendocrinology, in press. |
| Merali, Z., Hayley, S., Kent, P., McIntosh, J., Bédard, T.., & Anisman, H. (2009). Impact of repeated stressor exposure on the release of corticotropin-releasing factor, arginine-vasopressin and bombesin-like peptides at the anterior pituitary. Behavioral Brain Research, 198, 105-112. |
| Audet, M-C., & Anisman, H. (2009). Neuroendocrine and neurochemical impact of aggressive social interactions in submissive and dominant mice: implications for stress-related disorders. International Journal of Neuropsychopharmacology, 23, 1-12. |
| Anisman, H., Merali, Z., Matheson, K., & Abizaid, A. Stress, Trauma and Substance Abuse/Dependence. In F. Vaccarino (Ed). Substance Abuse in Canada, 2009. |
| Mountney, C., Anisman, H., & Merali, Z. (2008). The role of gastrin releasing peptide agonist and antagonist administered to the basolateral nucleus of the amygdala in conditioned fear. Psychopharmacology, 200, 51-58. |
| Merali, M., Anisman, H., James, J., Kent, P., & Schulkin, J. (2008). Effects of corticosterone on CRH and gastrin-releasing peptide release in response to an aversive stimulus in two regions of the forebrain: central nucleus of the amygdala and prefrontal cortex. European Journal of Neuroscience, 28, 165-172. |
| Anisman, H. (2008). Stress. In G. Adelman (Ed). The Corsini Encyclopedia of Psychology and Behavioral Science, Wiley, N.Y. |
| Anisman, H., Merali, Z., & Stead, J.D. (2008). Experiential and Genetic Contributions to the Protracted Effects of Stressors: from adaptation to mental diseases. Neuroscience and Biobehavioral Reviews, 32, 1185-1206. |
| Roy, V., Poulter, M.O., Merali, Z., & Anisman, H. (2007). Anxiety responses, plasma corticosterone and central monoamine variations elicited by stressors in reactive and nonreactive mice and their reciprocal F1 hybrid. Behavioral Brain Research, 185, 49-58. |
| Anisman, H., Prakash, P., Merali, Z., & Poulter, M.O. (2007). Corticotropin Releasing Hormone Receptor Alterations Elicited by Acute and Chronic Unpredictable Stressor Challenges in Stressor-Susceptible and Resilient Strains of Mice. Behavioral Brain Research, 181, 180-190. |
| Prakash, P., Merali, Z., Kolajova, M., Tannenbaum, B.M., & Anisman, H., (2006). Influence of maternal factors on anxiety and neurochemical changes in stress resilient and susceptible mice: Analysis using a cross-fostering paradigm. Brain Research, 1111, 122-133. |
| Mountney, C., Sillberg, V., Kent,P., Anisman,H., and Merali, Z. (2006). The Role of Gastrin-Releasing Peptide in the Prelimbic and Infralimbic Cortices and Central Nucleus of the Amygdala in Conditioned Fear. Psychopharmacology, 189, 287-296. |
| Zhang, T-Y., Bagot, R., Parent, C., Nesbitt, C., Bredy, T.W., Caldji, C., Fish, E., Anisman, H., Szyf, M., & Meaney, M.J., (2006). Maternal programming of defensive responses through sustained effects on gene expression. Biological Psychiatry, 73, 72-89. |
| Anisman, H. & Matheson, K. (2005) Anhedonia and Depression: Caveats Concerning Animal Models. Neuroscience and Biobehavioral Reviews, 29, 525-546. |
| DiBattista, J.D., Anisman, H., Whitehead, M., & Gilmour, K.D. (2005). The effects of cortisol administration on social status and brain monoaminergic activity in rainbow trout (Oncorhynchus mykiss). The Journal of Experimental Biology, 208, 2707-2718. |
| Caldji, C., Diorio, J., Prakash, P., Anisman H., & Meaney, M.J. (2004). Maternal behavior regulates Benzodiazepine/GABAA receptor subunit expression in brain regions associated with fear in BALB/cByJ and C57BL/6ByJ mice. Neuropsychopharmacology, 29, 1344-1352. |
| Merali, Z., Michaud, D., McIntosh, J., Kent, P. & Anisman, H. (2003). Differential involvement of amygdaloid CRH system(s) in the salience and valence of the stimuli. Prog. Neuro-psychopharmacol. Biological Psychiatry, 27, 1201-1212. |
| Tannenbaum, B.M., Tannenbaum, G.S., & Anisman, H. (2003). Impact of life-long macronutrient choice on neuroendocrine and cognitive functioning in aged mice: differential effects in stressor-reactive and stressor resilient mouse strains. Brain Research, 985, 187-197. |
| Michaud, D.S., McLean, J., Keith, S.E., Ferrarotto, C., Haley, S., Khan, S., Anisman, H., & Merali. Z. (2003). Differential impact of audiogenic stressors on lewis and Fischer rats: behavioral, neurochemical, and endocrine variations. Neuropsychopharmacology, 28, 1068-1081. |
| Tannenbaum, B. & Anisman, H. (2003). Impact of Chronic Intermittent Challenges in Stressor-Susceptible and Resilient Strains of Mice. Biological Psychiatry, 53, 292-303. |
| Tannenbaum, B., Tannebaum, G., & Anisman, H. (2002). Neurochemical and behavioral alterations elicited by a chronic intermittent stressor regimen: Implications for allostatic load. Brain Research, 953, 82-92. |
| Anisman, H., Griffiths, J., Matheson, K., Ravindran, A.V., & Merali, Z. (2001). Posttraumatic stress symptoms following a severe ice storm: Salivary cortisol and behavioral correlates. The American Journal of Psychiatry, 158, 1511-1513. |
| Anisman, H., Hayley, S., Kelly, O., Borowski, T., & Merali, Z. (2001). Psychogenic, neurogenic and systemic stressor effects on plasma corticosterone and behaviors: Mouse strain-dependent outcomes. Behavioral Neuroscience, 115, 443-454. |
| Anisman, H. & Merali, Z. (2001). Rodent Models of Depression: Learned helplessness induced in mice. In J. Crawley (Ed.), Current Protocols in Neuroscience. Wiley, New York, 8.10C.1-8.10C.15. |
| Hayley, S , Borowski, T. Merali, Z., & Anisman, H. (2001). Central monoamine activity in genetically distinct strains of mice following a psychogenic stressor: effects of predator exposure, Brain Research, 892, 293-300. |
| Merali, Z., Kent, P., Michaud, D., McIntyre, D., & Anisman, H. (2001). Differential effects of psychogenic and neurogenic stressors on central corticotropin-releasing hormone and bombesin-like peptides in the Fast and Slow seizing rat. Brain Research, 906, 60-73. |
| Anisman, H., Kelly, O., Hayley, S., Borowski, T., Merali, Z., & McIntyre, D.C. (2000). Acoustic startle and fear potentiated startle in rats selectively bred for fast and slow kindling rates: Relation to monoamine activity. European Journal of Neuroscience, 12, 4405-4416. |
| Anisman, H. & Merali, Z. (2000). Understanding stress: Characteristics and caveats. Alcohol: Research and Health (Special issue), 23, 241-249. |
| Plata-Salamán, C.R., Ilyin, S.E., Turrin, N.P., Gayle, D., Flynn, M.C., Bedard, T., Merali, Z., & Anisman, H. (2000) Neither Acute nor Chronic Exposure to a Naturalistic (predator) Stressor influences the IL-1b system, TNF-a, TGF-b1, and neuropeptide mRNAs, CRH or Bombesin Content in Specific Brain Regions. Brain Research Bulletin, 51, 187-193. |
| Khan, S., Michaud, D., Moody, T.W., Anisman, H., & Merali, Z. (1999). Effects of acute restraint stress on endogenous adrenomedullin levels. NeuroReport, 10, 2829-2833. |
| McIntyre, D.C., Hayley, S., Kent, P., Merali, Z., & Anisman, H. (1999). Influence of psychogenic and neurogenic stressors on neuroendocrine and central monoamine activity in fast and slow seizing rats. Brain Research, 840, 65-74. |
| Connor, T.J., Song, C., Leonard, B.E., Merali, Z., & Anisman, H. (1999). Stressor-induced alterations in serotonergic activity in an animal model of depression. NeuroReport, 10: 523-528. |
| McIntosh, J., Anisman, H., & Merali, Z. (1999). Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects. Developmental Brain Research, 113, 97-106. |
| Merali, Z., McIntosh, J., Kent, P., Michaud, D., &. Anisman, H. (1998) Aversive as well as appetitive events evoke the release of corticotropin releasing hormone and bombesin-like peptides at the central nucleus of the amygdala. The Journal of Neuroscience, 18, 4758-4766. |
| Adamec, R., Kent, P., Anisman, H., Shallow, T., & Merali, Z. (1998). Neural plasticity, neuropeptides and anxiety in animals: Implications for understanding and treating affective disorder following traumatic stress in humans. Neuroscience and Biobehavioral Reviews, 23, 301-18. |
| Anisman, H., Zaharia, M.D., Meaney, M.J., & Merali, Z. (1998). Do early-life events permanently alter behavioral and hormonal responses to stressors?. International Journal of Developmental Neuroscience (Special Issue), 16, 149-164. |
| Anisman, H., Lacosta, S., McIntyre, D., Kent, P., & Merali, Z. (1998). Stressor-induced CRH, Bombesin, ACTH and corticosterone variations elicited in strains of mice differentially responsive to stressors. Stress, 2, 209-220. |
| Kent, P., Anisman, H., & Merali, Z. (1998). Are bombesin-like peptides involved in the mediation of the stress response. Life Sciences, 62, 103-114. |
Stressor effects: Immune and cytokine sequelae |
| Gibb, J., Hayley, S., Gandhi, R., Merali, Z., & Anisman, H. (2008). Synergistic Actions of Psychosocial and Endotoxin Challenges: Circulation Cytokine, Corticosterone and Behavioral Changes. Brain, Behavior and Immunity, 22, 573-589. |
| Kusnecov, A. & Anisman, H. (2008). Stress and Cytokines: Implications for cancer and its treatment. In C. Kaiser (Ed). Cancer growth and Progression. Kluwer Press, Boston. in press. |
| Hayley, S., Mangano, E., Strickland, M., & Anisman, H. (2008). Lipopolysaccharide and a social stressor influence behaviour, corticosterone and cytokine levels: Divergent actions in cyclooxygenase-2 deficient mice and wild type controls. J. Neuroimmunology, 197, 29-36. |
| Anisman, H., Poulter, M.O., Gandhi, R., Merali, Z., & Hayley, S. (2007). Interferon-alpha effects are exaggerated when administered on a psychosocial stressor backdrop: Cytokine, corticosterone and brain monoamine variations. Journal of Neuroimmunology, 186, 45-53. |
| Miguelez, M., Anisman, H., Weber, J-M., & Merali, Z. (2006). Effects of acute or chronic omega-3 and omega-6 polyunsaturated fatty acid treatment on behavioral, neuroendocrine and cytokine changes elicited by interleukin-1. Journal of Neuroimmunology, 181, 19-28. |
| Anisman, H. & Kusnecov, A. (2004). Stress and immunity in the rat. In Ian Q. Whishaw and Bryan Kolb (Eds.), The Behavior of the Laboratory Rat: A Handbook with Tests, Oxford University Press, Inc. |
| Anisman, H., Hayley, S., & Merali, Z. (2003). Neurochemical sequelae of cytokine activation: Parallels with stressor effects. Seventh Symposium on Catecholamines and other Transmitters in Stress. R. Kvetnansky (ed). Slovak Acad. Sci. |
| Anisman, H., Hayley, S., Staines, W., & Merali, Z. (2001). Cytokines, Stress, and Neurochemical change: Immediate and Proactive effects. In: C.A.Shaw and J.C. McEachern (eds); Towards a theory of Neuroplasticity. Psychology Press, Philadelphia. pp. 301-320. |
| Lacey, K., Zaharia, M.D., Griffiths, J., Ravindran, A.V., Merali, Z., & Anisman, H. (2000). Aprospective study of neuroendocrine and immune alterations associated with the stress of an oral examination among graduate students. Psychoneuroendocrinology, 25: 339-356. |
| Lu Z.W., Hayley, S., Ravindran, A.V., Merali, Z., & Anisman, H. (1999). Influence of psychosocial, psychogenic and neurogenic stressors on several aspects of immune functioning in mice. Stress, 3, 55-70. |
| Lu, Z.W., Song, C., Ravindran, A.V., Merali, Z., & Anisman, H. (1998). Influence of psychogenic and neurogenic stressors on several indices of immune functioning in different strains of mice. Brain, Behaviour and Immunity, 12, 7-22. |
| Anisman, H., Lu, Z.W., Song, C., Kent, P., McIntyre, D.C.. & Merali, Z. (1997). Influence of psychogenic and neurogenic stressors on endocrine and immune activity: differential effects in fast and slow seizing rat strains. Brain, Behaviour and Immunity, 11, 63-74. |
| Ravindran, A.V., Griffiths, J., Merali, Z., & Anisman, H. (1997). Variations of lymphocyte subsets associated with stress in depressive populations. Psychoneuroendocrinology, 21, 659-671. |
| Kerr, L., Drummond, L., Zaharia, M., & Anisman, H. (1996). Stressor-induced alterations of the splenic plaque forming cell response. Pharmacology, Biochemistry and Behavior, 53, 235-242. |
Cytokine-Brain interactions |
| Magalhaes, A, Holmes, K., Dale, L.B., Drysdale, L., Comps-Agrar, L., Lee, D., Poulter, M., Pin, J.P., Anisman, H., & Ferguson, S.S.G. (2009). Endocytosis and recycling dependent enhancement of 5-HT2 receptor signaling by CRF. Nature Neuroscience, in revision. |
| Gibb, J., Audet, M.C., Hayley, S., & Anisman, H. (2009). Neurochemical and behavioral responses to inflammatory immune stressors. Frontiers in Bioscience, 1, 275-95. |
| Anisman, H., Gibb, J., & Hayley, S. (2008). Influence of continuous infusion of interleukin-1 on depression-related processes: Corticosterone, circulating cytokines, brain monoamines and cytokine mRNA expression. Psychopharmacology, 199, 231-244. |
| Gandhi, R., Hayley, S., Gibb, J., Merali, Z., & Anisman, H (2007). Influence of Poly I:C on Sickness Behaviors, Plasma Cytokines, Corticosterone and Central Monoamine Activity: Moderation by Social Stressors. Brain, Behavior and Immunity, 21, 477-489. |
| Mount, M.P., Lira, A., Grimes, D., Smith, P.D., Faucher, S., Slack, R., Anisman, H., Hayley, S., & Park, D. (2007). Involvement of interferon-gamma in microglial mediated loss of dopaminergic neurons. The Journal of Neuroscience, 27, 3328-3337. |
| Hayley, S., Poulter, M. Merali, Z., & Anisman, H. (2005). The pathogenesis of clinical depression: Stressor and cytokine induced alterations of neuroplasticity. Neuroscience, 135, 659-678. |
| Hayley, S., & Anisman, H. (2005). Multiple mechanisms of cytokine action in neurodegenerative and psychiatric states: neurochemical and molecular substrates. Current Pharmaceutical Design, 11, 947-962. |
| Anisman, H., Poulter, M., Merali, Z., & Hayley, S. (2005). Cytokines as a precipitant of depressive illness: animal and human studies. Current Pharmaceutical Design, 11, 963-972. |
| Anisman, H. (2004). Considering cytokine panels. Brain, Behavior & Immunity, 18, 221-222. |
| Sudom, K., Turrin, N., Hayley, S., & Anisman, H. (2004). Influence of chronic interleukin-2 infusion and stressors on sickness behaviors and neurochemical change in mice. Neuroimmunommunomodulation, 11, 341-350. |
| Hayley, S., Kelly, O.P., & Anisman, H. (2004). Corticosterone changes in response to stressors, acute and protracted actions of tumor necrosis factor-a, and lipopolysaccharide treatments in mice lacking the tumor necrosis factor-a p55 receptor gene. Neuroimmunomodulation, 11, 241-246. |
| Michaud, D.S., McLean, J., Keith, S.E., Ferrarotto, C., Haley, S., Khan, S., Anisman, H., & Merali, Z. (2003). Differential impact of audiogenic stressors on lewis and Fischer rats: behavioral, neurochemical, and endocrine variations. Neuropsychopharmacology, 28, 1068-1081. |
| Anisman, H. & Hayley, S. (2003). Tumor Necrosis Factor- Affects Central Neurotransmission: Neuropsychiatric Disorders and Neurodegenerative Processes. In Adelman, G., and Smith, B. (Eds). Encyclopedia of Neuroscience, Elsevier, New York. |
| Anisman, H., Turrin, N.P., Merali, Z., & Hayley, S. (2003). Neurochemical Sensitization Associated with Systemic Administration of Tumor Necrosis Factor-a: Adjuvant Action in Combination with Bovine Serum Albumin. Journal of Neuroimmunology, 945, 91-102. |
| Merali, Z., Brennan, K., Brau, P., & Anisman, H. (2003). Dissociating Anorexia and Anhedonia Elicited by Interleukin-1b: Antidepressant and Gender Effects on Responding for "Free Chow" and "Earned" Sucrose Intake. Psychopharmacology, 165, 413-418. |
| Anisman, H., Hayley, S., & Merali, Z. (2003). Sensitization associated with stressors and cytokine treatments. Brain, Behavior & Immunity, 17, 86-93. |
| Hayley, S., Merali Z., & Anisman, H. (2003). Cytokine-elicited sensitization: neuroendocrine, neurotransmitter and behavioral responses. In Z. Kronfol (Ed.). Cytokines and Mental, Kluwer Academic Publishers. |
| Anisman, H. & Merali, Z. (2002) Cytokines, Stress, and Depressive Illness. Brain, Behavior & Immunity, 16, 513-524 |
| Anisman, H., Kokkinidis, L., & Merali, Z. (2002). Further Evidence for the Depressive Effects of Cytokines: Anhedonia and Neurochemical Changes. Brain, Behavior & Immunity, 16, 544-556. |
| Hayley, S., Kelly, O. &. Anisman, H. (2002). Murine tumor necrosis factor a sensitizes plasma corticosoterone and manifestation of shock: Modulation by histamine. Journal of Neuroimmunology, 131, 60-69. |
| Hayley, S., Wall, P., &. Anisman, H. (2002). Sensitization to the Neuroendocrine, Central Monoamine and Behavioral Effects of murine Tumor Necrosis Factor-a: Peripheral and central mechanisms. European Journal of Neuroscience, 15, 1061-1076. |
| Hayley, S., Staines, W.M., Merali, Z., & Anisman, H. (2001). Time-Dependent Sensitization of Corticotropin Releasing Hormone, Arginine Vasopressin and c-fos Immunoreactivity Within the Mouse Brain in Response to Tumor Necrosis Factor-a. Neuroscience, 106, 137-148. |
| Anisman, H., Hayley, S., & Merali, Z. (2001). Behavioral and central neurochemical consequences of cytokine challenge. In J. Bienenstock, R. Gorzynski and I. Berczi (Eds) Neuroimmune Biology: New Foundation of Biology. Elsevier Science, pp. 141-162. |
| Anisman, H., Hayley, S., Ravindran, A.V., Merali, Z., & Griffiths, J. (2001). Cytokines, Stress and Depressive illness. In A.J. O'Neill and A. Bowie (Eds.). Methods in Molecular Medicine. Vol. 60. Interleukin Protocols. Human Press, Totowa, New Jersey, pp. 217-238. |
| Hayley, S., Lacosta, S., Merali Z., van Rooijen, N., & Anisman, H. (2001). Central Monoamine and Plasma Corticosterone Changes Induced by a Bacterial Endotoxin: Sensitization and Cross-sensitization Effects. European Journal of Neuroscience, 13, 1155-1165. |
| Lacosta, S., Merali, Z., & Anisman, H. (2000). Central monoamine alterations associated with acute and repeated interleukin-2 administration. Neuroimmunomodulation, 9, 1-16. |
| Brebner, K., Hayley, S., Merali, Z., & Anisman, H. (2000). Synergistic effects of interleukin-1, interleukin-6, and TNF-a: neuroendocrine, neurochemical and behavioral changes. Neuropsychopharmacology, 22, 566-580. |
| Pu, S., Anisman, H., & Merali, Z. (2000). Central infusion of interleukin-1 receptor antagonist fails to alter feeding and weight gain. Neuroreport, 11, 1699-702. |
| Lacosta, S., Merali, Z., & Anisman, H. (1999). Effects of acute and repeated interleukin-2 administration on spatial learning, locomotor activity, exploratory behaviors and anxiety. Behavioral Neuroscience, 113, 1030-1041. |
| Hayley, S., Brebner, K., Lacosta, S., Merali, Z., & Anisman, H. (1999). Sensitization to the effects of tumor necrosis factor-a; neuroendocrine, central monoamine and behavioral variations. The Journal of Neuroscience, 19, 5654-5665. |
| Anisman, H. & Merali, Z. (1999). Anhedonic and anxiogenic effects of cytokine exposure. Advances in Experimental Medicine and Biology, 461, 199-233. |
| Lacosta, S., Merali, Z., & Anisman, H. (1999). Behavioral and neurochemical consequences of lipopolysaccharide in mice: anxigenic-like effects. Brain Research, 818, 291-303. |
| Borowski, T., Kokkinidis, L., Merali, Z., & Anisman, H. (1998). Lipopolysaccharide, central in vivo biogenic amine variations, and anhedonia. NeuroReport, 9, 3797-3802. |
| Song, C., Merali, Z., & Anisman, H. (1998). Variations of nucleus accumbens dopamine and serotonin following systemic interleukin-1, interleukin-2 or interleukin-6 treatment. Neuroscience, 88, 823-836. |
| Connor, T.J., Song, C., Leonard, B.E., Merali, Z., & Anisman, H. (1998). An assesment of the effects of central interleukin-1, -2, -6, and tumor necrosis factor-a administration on some behavioral, neurochemical, endocrine and immune parameters in the rat. Neuroscience, 84, 923-933. |
| Lacosta, S., Merali, Z., & Anisman, H. (1998). Influence of interleukin-1 on exploratory behaviors, plasma ACTH and cortisol, and central biogenic amines in mice. Psychopharmacology, 137, 351-361. |
| Anisman, H., Kokkinidis, L., Borowski, T., & Merali, Z.(1998). Differential effects of IL-1, IL-2 and IL-6 on responding for rewarding lateral hypothalamic stimulation. Brain Research, 779, 177-187. |
| Hebb, A.L.O., Zacharko, R.M., & Anisman, H. (1998). Self-stimulation from the mesencephalon following intraventricular interleukin-2 administration. Brain Research Bulletin, 45, 549-556. |
| Merali, Z., Lacosta, S., & Anisman, H. (1997). Effects of interleukin-1b and mild stress on alterations of central monoamines: A regional microdialysis study. Brain Research, 761, 225-235. |
| Zacharko, R., Zalcman, S., MacNeil, G., Andrews, M., Mandella, P.D., & Anisman, H. (1997). Differential effects of immunologic challenge on self-stimulation from the nucleus accumbens and the substantia nigra. Pharmacology, Biochemistry and Behavior, 58, 881-886. |
| Anisman, H., Baines, M.G., Berczi, I.*, Bernstein, C.N., et al.,. (1996). Neuroimmune mechanisms in health and disease: 1. Health. Canadian Medical Association Journal, 155, 867- 874. (*corresponding author) |
| Anisman, H., Baines, M.G., Berczi, I.*, Bernstein, C.N., et al., (1996) Neuroimmune mechanisms in health and disease: 2. Disease. Canadian Medical Association Journal, 155, 1075-1082. (*corresponding author) |
| Anisman, H., Merali, Z., & Kokkinidis, L. (1996) Interleukin-2 decreases accumbal dopamine efflux and responding for rewarding lateral hypothalamic stimulation. Brain Research, 731, 1-11. |
Depression: Pharmacotherapy, neuroendocrine and cytokine functioning |
| Chopra, K.K., Ravindran, A., Kennedy, S.H., Mackenzie, B., Matthews, S., Anisman, H., Bagby, R.M., Farvolden, R., & Levitan, R.D. (2009). Sex differences in hormonal responses to a social stressor in chronic major depression. Psychoneuroendocrinology 34, 1235-1241. |
| Anisman, H. (2009). Cascading effects of stressors and inflammatory immune system activation: Implications for major depressive disorder. Journal of Psychiatry and Neuroscience, 34, 4-20. |
| Anisman, H., Merali, Z., & Hayley, S. (2008). Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: Comorbidity of depression with neurodegenerative disorders. Progress in Neurobiology, 85, 1-74. |
| Anisman, H., Matheson, K., & Hayley, S. (2008). Neurochemical and transmitter models of depression. Risk Factors for Depression. K.S. Dobson, & D. Dozois Eds. Elsevier Science, N.Y. Pp 63-90. |
| Mennigen, J.A., Martyniuk, C.J., Crump, K., Xiong, H., Zhao, E., Popesku, J., Anisman, H., Cossins, A.R., Xia, X., & Trudeau, V.L. (2008). The effects of fluoxetine on the reproductive axis of female goldfish (Carassius auratus). Physiological Genomics, 35, 273-282. |
| Poulter, M.O., Du, L., Zhurov, I.V., Palkovits, M., Faludi, G., Merali, Z., & Anisman, H. (2008). Altered organization of GABAA receptor mRNA expression in the depressed suicide brain: Parallels in stressor sensitive vs resilient mice. Psychiatry Research, In revision. |
| Anisman, H., Merali, Z., & Hayley, S. (2007) Depressive Disorders: Contribution of Cytokines and other Growth Factors. In. Handbook of Clinical Psychology, Wiley. |
| Hayley, S., Poulter, M., Merali, Z., & Anisman, H. (2005). The pathogenesis of clinical depression: Stressor and cytokine induced alterations of neuroplasticity. Neuroscience, 135, 659-678. |
| Anisman, H., Poulter, M., Merali, Z., & Hayley, S. (2005). Cytokines as a precipitant of depressive illness: animal and human studies. Current Pharmaceutical Design, 11, 963-972. |
| Anisman, H. & Matheson, K. (2004). Anhedonia and Depression: Caveats Concerning Animal Models. Neuroscience and Biobehavioral Reviews, 29, 525-546. |
| Hayley, S., Merali, Z., & Anisman, H. (2003). Stress and Cytokine-elicited Neuroendocrine and Neurotransmitter Sensitization: Implications for Depressive Illness. Stress, 6, 19-32. |
| Anisman, H. & Merali, Z. (2003). Cytokines, Stress and Depressive illness: Brain-Immune Interactions. Annals of Medicine, 35, 2-11. |
| Anisman, H. (2002) Stress, Immunity, Cytokines, and Depression. Acta Neuropsychiatrica, 14, 251-261. |
| Anisman, H., Hayley, S., Turrin, N., & Merali, Z. (2002). Cytokines as a stressor: implications for depressive illness. International Journal of Neuropsychopharmacology, 5, 357-373. |
| Hayley, S., Merali, Z., & Anisman, H. (2002). Cytokines and sensitization: Contribution to depression. Acta Neuropsychiatrica, 14, 322-335. |
| Ravindran, A.V., Matheson, K., Griffiths, J, Merali, Z., & Anisman, H. (2002). Stress, coping, uplifts, and quality of life in subtypes of depression. Journal of Affective Disorders, 71, 121-131. |
| Griffiths, J., Ravindran, A.V., & Merali, Z. & Anisman, H. (2000). Dysthymia: Neurochemical and behavioral perspectives. Molecular Psychiatry, 5, 242-261. |
| Zaharia M.D., Ravindran, A.V., Griffiths, J., Merali, Z., & Anisman, H. (2000). Lymphocyte proliferation among major depressive and dysthymic patients with typical or atypical features. Journal of Affective Disorders, 58, 1-10. |
| Anisman, H., Ravindran, A.V., Griffiths, J., & Merali, Z. (1999). Interleukin-1 beta production in dysthymia before and after pharmacotherapy. Biological Psychiatry, 46, 1649-55. |
| Ravindran, A.V., Lapierre Y.D., & Anisman, H. (1999). Obsessive-compulsive spectrum disorders: Effect of treatment with paroxetine. Canadian Journal of Psychiatry, 1999, 44, 805-807. |
| Ravindran, A.V., Anisman, H., Merali, Z., Charbonneau, Y., Telner, J., Bialik, R.J., Wiens, A., Ellis, J., & Griffiths, J. (1999). Treatment of primary dysthymia with cognitive therapy and pharmacotherapy: Clinical symptoms and functional Impairments. The American Journal of Psychiatry, 156, 1608-1617. |
| Anisman, H. & Merali, Z. (1999). Cytokines and stress in relation to anxiety and anhedonia. In R. Dantzer (Ed.) Cytokines, Stress and Depression. Plenum Press, New York. |
| Anisman, H., Ravindran, A.V., Griffiths, J., & Merali, Z. (1999). Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features. Molecular Psychiatry, 4, 182-188. |
| Ravindran, A.V., Knott, V.J., Griffiths, J., Merali, Z., & Anisman, H. (1999). Influence of tryptophan depletion on mood and immune measures in healthy males. Psychoneuroendocrinology, 24, 99-113. |
| Ravindran, A.V., Griffiths, J., Merali, Z., & Anisman, H. (1999). Circulating lymphocyte subsets in obsessive compulsive disorder, major depression and normal controls. Journal of Affective Disorders, 52, 1-10. |
| Ravindran, A.V., Charbonneau, Y., Zaharia, M., Al-Zaid, K., Wiens, A., & Anisman, H. (1998). Efficacy and tolerability of venlafaxine in the treatment of primary dysthymia. Journal of Psychiatry and Neuroscience, 23, 288-92. |
| Ravindran, A.V., Griffiths, J., Merali, Z., & Anisman, H. (1998). Circulating lymphocyte subsets in major depression and dysthymia with typical or atypical features. Psychosomatic Medicine, 60, 283-289. |
| Ravindran, A.V., Merali, Z., & Anisman H. (1997). Dysthymia: A Biological Perspective. In: J. Licinio, C.L. Bolis, & P. Gold (eds); Dysthymia: From Clinical Neuroscience to Treatment. WHO, 21-44. |
| Ravindran, A.V., Bialik, R., Hrdina, P., Merali, Z., Anisman, H., & Lapierre, Y. (1997). Neuroendocrine and anthropometric measures in major depression: The effect of antidepressant treatment. Human Psychopharmacology, 12, 583-589. |
| Griffiths, J., Ravindran, A.V., Merali, Z., & Anisman, H. (1997). Neuroendocrine measures and lymphocyte subsets in depressive illness: Influence of a clinical interview concerning life experiences. Psychoneuroendocrinology 24, 225-236. |
| Ravindran, A.V., Griffiths, J., Merali, Z., & Anisman, H. (1996). Primary dysthymia: A study of several psychosocial, endocrine and immune correlates. Journal of Affective Disorders, 40, 73-84. |
| Ravindran, A., Griffiths, J., Waddell, C., & Anisman, H. (1995). Stressful life events and coping styles in dysthymia and major depressive disorder: Variations associated with alleviation of symptoms following pharmacotherapy. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19, 637-653. |
| Ravindran, A., Griffiths, J., Merali, Z., & Anisman, H. (1995). Lymphocyte subsets in major depression and dysthymia: Modification by antidepressant treatment. Psychosomatic Medicine, 57, 555-563. |
Eating and Anxiety |
| Tannebaum, B., Anisman, H., & Abizaid, A. (2009). Neuroendocrine Stress Response and Its Impact on Eating Behaviour and Body Weight. In Dube, L., Bechara, A., Dagher, A., Drewnowski, A., LeBel, J., James, P., Richard, D & Yada, R.Y. Role of Society and Brain on Individual Behavior, in press. |
| Merali, Z., Cayer, C., Kent, P., & Anisman, H. (2008). Nesfatin-1 increases anxiety and fear-related behaviors in the rat. Psychopharmacology, 210, 115-123. |
| Bédard, T., Mountney, C., Kent, P., Anisman, H., & Merali, Z. (2007). Role of gastrin-releasing peptide and neuromedin B in anxiety and fear-related behavior. Behavioural Brain Research, 179, 133-140. |
| Merali, Z., Bédard, T., Andrews, N., Davis, B., McKnight, A.T., Gonzalez, I., Pritchard, M., Kent, P., & Anisman, H. (2006). Bombesin receptors as novel anti-anxiety therapeutic target; non-peptide antagonist PD 176252 reduces anxiety and 5-HT release through BB1 receptor. The Journal of Neuroscience, 26, 10387-10396. |
| Merali Z., Khan, S., Michaud, D.S., Shippy, S., & Anisman, H. (2004). Does amygdaloid corticotropin-releasing hormone (CRH) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRH release. European Journal of Neuroscience, 20, 229-239. |
| Kelly, O.P., McIntosh, J., McIntyre, D.C., Merali, Z., & Anisman, H . (2003). Anxiety in rats selectively bred for fast and slow kindling rates: situation-specific outcomes. Stress, 6, 289-295. |
| Merali, Z., Levac, C., & Anisman, H. (2003). Validation of a Simple, Ethologically Relevant Paradigm for Assessing Anxiety in mice. Biological Psychiatry, 54, 552-565. |
| Merali, Z., Kent, P., & Anisman, H. (2002). Role of bombesin-related peptides in the mediation or integration of the stress response, Cellular and Molecular Life Sciences, 59, 272-287. |
| Kent, P., Anisman, H., & Merali, Z. (2001). Central bombesin activates the hypothalamic-pituitary-adrenal axis: Effects on regional levels and release of corticotropin-releasing hormone and arginine vasopressin. Neuroendocrinology, 73, 203-214. |
| Merali, Z., Kent, P., Michaud, D., McIntyre, D., & Anisman, H. (2001). Differential effects of psychogenic and neurogenic stressors on central corticotropin-releasing hormone and bombesin-like peptides in the Fast and Slow seizing rat. Brain Research, 906, 60-73. |
| Kent, P., Bedard, T., Khan, S., Anisman, H., & Merali, Z. (2001). Bombesin-induced HPA and sympathetic activation requires CRH receptors. Peptides, 22, 57-65. |
| McIntyre, D.C. and Anisman, H. (2000) Anxiety and impulse control in rats selectively bred for seizure sensitivity. In M. Mysblodsky and I. Weiner (Eds.), Contemporary Issues in Modeling Psychopathology. Kluwer Academic, New York, pp. 29-34. |
| Merali, Z., McIntosh, J., & Anisman, H. (1999). Role of bombesin-related peptides in the control of food intake: A review. Neuropeptides, 33, 376-386. |
| Michaud, D., Anisman, H.. & Merali, Z. (1999). Capsaicin-sensitive fibers are required for the anorexic action of systemic but not central bombesin. American Journal of Physiology, 276, R1617-R1622. |
Psychosocial Stress |
| Matheson, K., & Anisman, H. (2010). Red fish, blue fish: Biological and psychosocial responses to discrimination. In J. Jetten, S.A. Haslam, & C. Haslam (Eds.), The social cure, in press. |
| Bombay, A., Matheson, K., & Anisman, H. (2009). The impact of stressors on second generation Indian Residential School Survivors. Transcultural Psychiatry, in press. |
| Matheson, K., Raspopow, K., & Anisman, H. (2009). Bearing Witness: Observer Responses to Sex Discrimination as a Function of the Emotions Conveyed by the Victim. British Journal of Social Psychology, submitted. |
| Bombay, A., Matheson, K., & Anisman, H. (2009). Intergenerational Trauma among First Nations: Communities in Crisis. Journal of Aboriginal Health National Aboriginal Health Organization: Ottawa, ON. In press. |
| Ysseldyk, R., Matheson, K., Sudom, K. & Anisman, H. (2009). Forgiveness and the appraisal coping process in response to relationship conflicts: Implications for depressive affect. Stress, 12, 152-166. |
| Jorden, S., Matheson, K., & Anisman, H. (2009). Resilience among Somali refugees: Supportive and unsupportive social interactions in relation to cultural adaptation and psychological well-being. Journal of Cross-Cultural Psychology, 40, 853-874. |
| Matheson, K. & Anisman, H. (2009). Anger and shame elicited by discrimination: Moderating role of coping on action endorsements and salivary cortisol. European Journal of Social Psychology, 39, 163-185. |
| Matheson, K., Gill, R., Kelly, O., & Anisman, H. (2008). Cortisol and Cardiac Reactivity in the Context of Sex Discrimination:The Moderating Effects of Mood and Perceived Control. The Open Psychology Journal, 1, 1-11. |
| Matheson, K., Jorden, S., & Anisman, H. (2007). Relations Between Trauma Experiences and Psychological, Physical and Neuroendocrine Functioning Among Somali Refugees: Mediating Role of Coping with Acculturation Stressors. Journal of Immigrant and Minority Health, 10, 291-304. |
| Kelly, O., Matheson, K., Martinez, A., Merali Z., & Anisman H. (2007). Psychosocial stress evoked by a virtual audience: relation to neuroendocrine activity. Cyberpsychology and Behavior, 10, 655-662. |
| Ysseldyk, R., Matheson, K., & Anisman, H. (2007). Rumination: Bridging a gap between forgivingness, vengefulness, and psychological health. Personality and Individual Differences, 42, 1573-1584. |
| Cole, B., Matheson, K., & Anisman, H. (2007). Academic performance and well-being: Moderating role of ethnic identity & social support. Journal of Applied Social Psychology, 37, 592-615. |
| Matheson, K., Skomorovsky, A., Fiocco, A., & Anisman, H. (2007). The limits of 'adaptive' coping: Well-being and affective reactions to stressors among women in abusive dating relationships. Stress, 10, 75-92. |
| Skomorovsky, A., Matheson, K., & Anisman, H. (2006). When social support is not enough: Moderating effects of social support perceptions and abuse in dating relationships on eating disturbances. Sex Roles, 54, 627-638. |
| Matheson, K., Kelly, O., Cole, B., Tannenbaum, B., Dodd, C., & Anisman, H. (2005). Parental Bonding and Depression: The Mediating Role of Personal, Social and Coping Resources. British Journal of Social Psychology, 44, 371-395. |
| Mantler, J., Matejicek, A., Matheson, A., & Anisman, H. (2005). Coping with employment uncertainty: A comparison of employed and unemployed workers. Journal of Occupational Health Psychology, 10, 200-209. |
| Matheson, K. & Anisman, H. (2003). Systems of Coping Associated with Psychological Distress: A Profile Perspective. Stress, 6, 223-234. |
Associated Projects |
| Matheson, K., Wohl, M., & Anisman, H. (2009). The Interplay of Appraisals, Specific Coping Styles, and Depressive Symptoms Among Young Male and Female Gamblers. Social Psychology, in press. |
| Wohl, M. J. A., Christie, K. L., Matheson, K., & Anisman, H. (2009). Animation-based education as gambling prevention tool: Correcting erroneous cognitions and reducing the frequency of exceeding limits among gamblers. Journal of Gambling Studies, in press. |
| Ysseldyk, R., Matheson, K., & Anisman, H. (2009). Religiosity as Identity: Toward an Understanding of Religion from a Social Identity Perspective. Personality and Social Pschology Review, in press. |
| Anisman, H., Du, L., Palkovits, M., Faludi, G., Kovacs, G.G., Szontagh-Kishazi, P., Merali, Z., & Poulter, M.O. (2008). Serotonin Receptor Subtype and p11 mRNA Expression in Stress-Relevant Brain Regions of Suicides and Controls. Journal of Psychiatry and Neuroscience, 33, 131-141. |
| Poulter, M.O., Du, L., Weaver, I., Palkovits, M., Faludi, G., Merali, Z., Szyf, M. & Anisman, H. DNA (2008). GABA(A) Receptor Promoter Hypermethylation in Suicide Brain: Implications for the Involvement of Epigenetic Processes. Biological Psychiatry, 64, 645-652. |
| Wohl, M. J. A., Lyon, M., Young, M. M., Donnelly, C., Matheson, M., & Anisman, H. (2008). Episodic cessation of Gambling: A Numerically Aided Phenomenological Analysis. International Gambling Studies, 8, 249-264. |
| Wohl, M. J. A., Christie, K. L., Matheson, K., & Anisman, H. (2008). Can animation-based education correct erroneous cognitions and reduce the frequency of exceeding limits among slots players?.[Research Report]. Guelph, ON: Ontario Problem Gambling Research Centre. |
| Young, M.M., Wohl, M.J., Matheson, K., Baumann, S., & Anisman, H. (2008). The Desire to Gamble: The Influence of Outcomes on the Priming Effects of a Gambling Episode. Journal of Gambling Studies, 24, 275-293. |
| Wohl, M. J. A., Lyon, M., Young, M. M., Donnelly, C., Matheson, M., & Anisman, H. (2008). Episodic cessation of Gambling: A Numerically Aided Phenomenological Analysis. International Gambling Studies, 8, 249-264. |
| Wohl, M.J.A., Matheson, K., Young, M.M. & Anisman, H. (2008). Cortisol Rise Following Awakening among Problem Gamblers: Dissociation from Comorbid Symptoms of Depression and Impulsivity. Journal of Gambling Studies, 24, 79-90. |
| Kelly, O., Matheson, K., Ravindrun, A., Merali, Z., & Anisman, H. (2007). Ruminative coping and dysthymia. Depression & Anxiety, 24, 233-243. |
| Wohl, M. J. A., Anisman, H., Matheson, K., & Young, M. M. (2006). Personal luck, outcome expectancies, and subjective appraisals as predictors of health and readiness to seek treatment among young adults. [Research Report]. Guelph, ON: Ontario Problem Gambling Research Centre. |
| Smith, P.D., Mount, M.P., Shree, R., Callaghan, S., Slack, R.S., Anisman, H., Vincent, I., Mao, X. & Park, D.S. (2006). A calpain regulated p35/cdk5 complex plays a central role in dopaminergic neuron death in vivo through modulation of the transcription factor MEF2. The Journal of Neuroscience, 26440-447. |
| Kim RH, Smith PD, Aleyasin H, Hayley S, Mount MP, Pownall S, Wakeham A, You-Ten AJ, Kalia SK, Horne P, Westaway D, Lozano AM, Anisman H, Park DS, Mak TW. (2005). Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proceedings of the National Academy of Sciences, 102, 5215-20. |
| Merali, Z., Kent, P., Du, L, Hrdina, P., Palkovits, M., Faludi, G., Poulter, M.O., Bédard, T., & Anisman, H. (2005). Corticotropin Releasing Hormone, Arginine Vasopressin, Gastrin Releasing Peptide And Neuromedin B Alterations in Stress-Relevant Brain Regions of Suicide Victims. Biological Psychiatry, 59, 594-602. |
| McIntyre, D.C., McLoed, W.S., & Anisman, H. (2004). Working and Reference Memory in Seizure Prone and Seizure Resistant Rats: Impact of Amygdala Kindling. Behavioral Neuroscience, 118, 314-323. |
| Merali, Z., McIntosh, J., & Anisman, H. (2004). Anticipatory cues differentially provoke in vivo peptidergic and monoaminergic release at the medial prefrontal cortex. Neuropsychopharmacology, 29, 1409-1418. |
| Merali, Z., Du, L., Hrdina, P., Palkovits, M., Faludi, G., Poulter, M.O., & Anisman, H. (2004). Dysregulation in the suicide brain: mRNA expression of Corticotropin Releasing Hormone Receptors and GABAA Receptor subunits in Frontal Cortical Brain Region. The Journal of Neuroscience, 24, 1478-1285. |
| Shin, R.S., Anisman, H., Merali, Z., McIntyre, D.C. (2004). Amygdala amino acid and monoamine levels in genetically Fast and Slow kindling rat strains during massed amygdala kindling: a microdialysis study. European Journal of Neuroscience, 20, 185-194. |
| Hayley, S., Crocker, S.J., Smith, P., Shree, T., Jackson-Lewis, V., Prezborski, S., Mount, M., Slack, R., Anisman, H., & Park, D.S. (2004). Regulation of dopaminergic loss by Fas in an MPTP model of Parkinson's disease. The Journal of Neuroscience, 24, 2045-2053. |
| Smith, P.D., Crocker, S.J., Jackson-Lewis, V., Jordan-Sciutto, K.L., Hayley, S., Mount, M.P., O'Hare, M.J., Callaghan, S., Slack, R.S., Przedborski, S., Anisman, H., & Park, D.S. (2003). Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences, 2003, 100, 13650-13655. |
| Crocker, S.J., Smith, P.D., Jackson-Lewis, V., Lamba, W.R., Hayley, S.P.., Grimm, E., Callaghan, S.M., Slack, R.S., Melloni, E., Przedborski, S., Robertson, G.S., Anisman, H., Merali, Z., & Park, D.S. (2003). Inhibition of Calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. The Journal of Neuroscience, 23, 4081-4091. |
| Crocker, S.J., Liston, P., Anisman, H., Lee, C.J., Smith, P.D., Earl, N., Thompson, C.S., Park, D.S., Korneluk, R.G., Robertson, G.S. (2003). Attenuation ofMPTP-induced neurotoxicity and behavioral impairment in NSE-XIAP transgenic mice. Neurobiology of Disease, Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice. Neurobiology of Disease, 12, 150-161. |
| Anisman, H. & McIntyre, D.C. (2002). Impulsivity and Attention Deficits in Rats Bred for Seizure Susceptibility. Iberoamericana de Información Científica, A4, 1-6. |
| Anisman, H. & McIntyre, D.C. (2002). Conceptual, spatial and cue learning in the morris water-maze in fast or slow kindling rats: attention deficit comorbidity. The Journal of Neuroscience, 22, 7809-7817. |
| Shin, R.S., Anisman, H., Merali, Z., & McIntyre, D.C. (2002). Changes in Extracellular Levels of Amygdala Amino Acids in Fast and Slow Kindling Rat Strains. Brain Research, 946, 31-42. |
| Brennan, K., Roberts, D. C. S., Anisman, H., & Merali, Z. (2001). Individual Differences in Sucrose Consumption: Motivational and neurochemical correlates of hedonia. Psychopharmacology, 157, 269-276. |
| Crocker, S.J., Lamba, W.R., Smith, P.D., Callaghan, S.M., Slack, R.S., Anisman, H. & Park, D.S. (2001). C-Jun mediates axotomy-induced dopamine neuron death in vivo. Proceedings of the National Academy of Sciences, 98,13385-13390. |
| Plata-Salaman, C.R., Ilyin, S.E., Turrin, N.P., Gayle, D., Flynn, M.C., Romanovitch, Kelly, M.E., Bureau, Y., Anisman, H., & McIntyre, D. (2000). Kindling modulates the IL-1beta system, TNF-alpha, TGF-beta 1 and neuropeptide mRNAs in specific brain regions. Brain Research. Molecular Brain Research, 75, 248-258. |
| Song, C., Vandewoude, M., Stevens, W, De Clerck, L., Van der Planken, M., Whelan, A., Anisman, H., Dossche, A., & Maes, M . (1999). Alterations in immune functions during normal aging and Alzheimer's disease. Psychiatry Research, 85, 71-80. |
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Modified & last updated by Hymie Anisman on December 4, 2009