The Ottawa-Carleton Chemistry Institut
The Ottawa-Carleton Chemistry Institute
2240 Herzberg Building
Telephone: 520-3515
Fax: 520-2569
The Institute
Director of the Institute, R.J. Crutchley
Associate Director of the Institute, To
be announced
The Ottawa-Carleton Chemistry Institute, established in 1981, is a joint program of
graduate studies and research in chemistry for Carleton University and the University
of Ottawa. The Institute combines the research strengths and resources of the
Departments of Chemistry at both campuses. Research
facilities are shared and include: a major mass spectrometry centre, X-ray spectrometer,
several modern NMR spectrometers, a pico-second laser facility, an ultratrace analysis
laboratory, and an electrochemical research
centre. In addition, the resources of many federal departments are available to graduate
students, including the National Research Council
and its library, the National Science Library
(CISTI), and departments of Health and Welfare and Agriculture.
The Institute offers the M.Sc. and Ph.D. degrees in all areas of chemistry, including
biochemistry, analytical, inorganic, organic,
physical and theoretical chemistry. All thesis,
seminar and examination requirements may be met in either English or French. Students will
be enrolled at the campus where the research supervisor is located. Several graduate
students also conduct their research off campus under the supervision of one of the
Institute's adjunct professors.
Application forms and further information may be obtained by writing to the director
of the Institute.
Ottawa-Carleton Collaborative Program in Chemical and Environmental Toxicology
The Departments of Chemistry and Biology at Carleton University and the University
of Ottawa, and the Department of Psychology at Carleton University, provide a
collaborative program in chemical and environmental
toxicology at the M.Sc. level. For further
details, see p.110.
Members of the Institute
* Howard Alper, Organometallic Chemistry
* A.D.O. Bawagan, Chemical Physics
* D.M. Bishop, Theoretical Chemistry
* G.W. Buchanan, Applications of NMR Spectroscopy
* P.H. Buist, Bio-organic Chemistry
* R.C. Burk, Environmental and Analytical Chemistry
* A.J. Carty, Organometallic and Inorganic Chemistry (Adjunct)
* C.L. Chakrabarti, Analytical Chemistry, Environmental Chemistry
* B.E. Conway, Electrochemistry and Surface Chemistry
* R.J. Crutchley, Physical Inorganic Chemistry
* Christian Detellier, Bio-inorganic Chemistry
* Tony Durst, Synthetic and Medicinal Organic Chemistry
* A.G. Fallis, Synthetic Organic Chemistry
* D.E. Fogg, Organometallic, Polymer and Materials Chemistry
* Sandro Gambarotta, Inorganic Chemistry
* B.R. Hollebone, Chemical Spectroscopy and Chemical Toxicology
* J.L. Holmes, Mass Spectroscopy
* K.U. Ingold, Physical Organic Chemistry, Free Radicals (Adjunct)
* Harvey Kaplan, Biochemistry
* Peeter Kruus, Solution Physical Chemistry, Ultrasonics
* E.P.C. Lai, Photoacoustic Spectroscopy, Analytical Chemistry
* Paul M. Mayer, Gas Phase Ion Chemistry
* D. Miller, Environmental Chemistry
* Mario Morin, Electrochemistry
* B.A. Morrow, Surface Chemistry and Catalysis
* R.J. Norstrom, Environmental Chemistry (Adjunct)
* D.S. Richeson, Inorganic, Solid State and Organometallic Chemistry
* J.A. Ripmeester, Colloid and Clathrate Chemistry (Adjunct)
* R. Roy, Glycobiology, Combinational and Medicinal Chemistry
* J.C. Scaiano, Photochemistry
* Alain St.-Amant, Theoretical and Computational Chemistry
* S. Scott, Surface Chemistry & Catalysis
* K.B. Storey, Enzyme Biochemistry, Biotechnology
* Heshel Teitelbaum, Chemical Kinetics
* C.S. Tsai, Enzyme Action and Yeast Cultures
* Z.Y. Wang, Synthetic Polymer Chemistry and Organic Chemistry
* J.S. Wright, Theoretical Chemistry
Master of Science
Admission Requirements
The normal requirement for admission to the program is an Honours B.Sc. degree in
Chemistry, with a B+ average in the last two
years and a B average overall. Applicants who
do not meet this requirement, or whose undergraduate degree is in another, closely
related field, may be accepted into the program,
but may be assigned extra courses.
Program Requirements
* A research thesis defended at an oral examination
* Two graduate courses (one semester each)
* One seminar course (two semesters)
Guidelines for Completion of Master's Degree
Full-time students in the master's program will normally complete the degree
requirements in two years. Part-time students will
normally complete the degree requirements in four years.
Doctor of Philosophy
Admission Requirements
The normal requirement for admission to the Ph.D. program is a B.Sc. or M.Sc. degree
in Chemistry.
Program Requirements (from B.Sc.)
* A research thesis defended before an examination board which includes an
external examiner
* A comprehensive examination in chemistry; the format of this examination
depends on the field of chemistry in which the student is conducting his/her research.
At
Carleton this normally takes the form of a research proposal
* Four graduate courses (one semester each)
* Two seminar courses (two semesters each)
Program Requirements (from M.Sc.)
Same as above, except that under exceptional circumstances only one seminar course
will be required and credit for up to two graduate courses may be given to reduce the
requirement for graduate courses from four to two.
Residence Requirements
For the M.Sc. degree:
* At least one year of full-time study
For the Ph.D. degree (from B.Sc.):
* At least three years of full-time study
For the Ph.D. degree (from M.Sc.):
* At least two years of full-time study
Guidelines for Completion of Doctoral Degree
Full-time students in the doctoral program will normally complete the degree
requirements in three years. Part-time students
will normally complete the degree requirements in six years.
Full-time students who enter the doctoral program directly from the B.Sc. program
will normally complete the degree requirements in four and one-half years. Part-time
students will normally complete the degree requirements in nine years.
Graduate Courses
Not all of the following courses are offered in a given year. For an up-to-date
statement of course offerings for 1999-2000,
please consult the Registration Instructions
and Class Schedule booklet published in the summer.
Chemistry 65.509 (CHM8150)
Special Topics in Molecular Spectroscopy
Topics of current interest in molecular spectroscopy. In past years, the following
areas have been covered: electronic spectra of diatomic and triatomic molecules and
their interpretation using molecular orbital diagrams; Raman and resonance
Raman spectroscopy; symmetry aspects of
vibrational and electronic levels of ions and
molecules in solids; the presence of weak and
strong resonant laser radiation. (Also listed as
Physics 75.522/PHY8122)
Chemistry 65.511 (CHM8181)
Chemical Physics of Electron-Molecule Collisions
Basic classical scattering theory and quantum mechanical scattering theory.
Experimental aspects, such as electron optics, electron
gun fundamentals, energy analyzers and electron detectors. Applications to the
understanding of the chemistry of materials.
Chemistry 65.512 (CHM8172)
Supercritical Fluids
Fundamental and practical aspects of the uses of supercritical fluids in the chemistry
laboratory. Thermodynamic treatment of high pressure multicomponent phase
equilibria, transport properties, solubilities,
supercritical fluid extraction and chromatography for
analytical purposes, reactions in supercritical
fluids, equipment considerations, new developments.
Chemistry 65.515 (CHM8171)
Computational Chemistry
Introduction to the theory, limitations, and applications of molecular mechanics,
molecular dynamics, Monte Carlo techniques,
genetic algorithms, semi-empirical molecular
orbital methods, and density functional methods. Introduction to the Unix operating
system, the internet, and hardware and software
considerations.
Chemistry 65.516 (CHM8170)
Quantum Chemistry
Molecular orbital theory and its application to chemistry. Self-consistent field method,
results for diatomic molecules. Configuration interaction and molecular dissociation.
Basis sets and molecular properties. Ab initio versus semi-empirical approaches.
Correlation diagrams for chemical reactions.
Polyatomic molecules and potential energy surfaces.
Chemistry 65.517 (CHM8161)
Physical Chemistry of Solutions
Major theoretical approaches and experimental methods used in the study of liquids
and solutions.
Prerequisite: A reasonable background knowledge in thermodynamics, quantum
chemistry, and statistical mechanics.
Chemistry 65.520 (CHM8152)
Surface Chemistry and Catalysis
Adsorption phenomena and isotherms, surface area of solids. Modern techniques in
surface chemistry and surface science such as electron diffraction, Auger
electron spectroscopy, photo-electron
spectroscopy, electron energy loss spectroscopy,
infrared and Raman spectroscopy. Current new techniques.
Chemistry 65.522 (CHM8131)
Physical Chemistry of Electrolytic Solutions
Properties of water, hydration of ions, ionic interaction, colloidal and polymeric
electrolytes. Ionization processes in solution.
Chemistry 65.523 (CHM8141)
Applied Electrochemistry
Selected topics in applied electrochemistry will be reviewed, including
metal electrodeposition, organic electrochemistry, performance of batteries,
electrochemical energy conversion, corrosion and
passivity. Electrochemistry at semiconductors.
Chemistry 65.524 (CHM8151)
Electrochemistry at Interfaces
Introduction to electrode processes and electrolysis. Potential differences at
interfaces. Characterization of the electrical double
layer. Dipole orientation effects; charge transfer
in absorbed layers; electrochemical origins of surface science concepts. Theory of
electron transfer; electrode kinetics;
electrocatalysis. Industrial applications; photo-electrochemistry.
Chemistry 65.527 (CHM8121)
Organic Reaction Mechanisms
Advanced physical organic chemistry, including topics such as: acidity functions, pKas
of organic compounds, steric and electronic effects in organic chemistry, molecular
orbital theory and correlation diagrams, structure
calculations using molecular mechanics.
Chemistry 65.528 (CHM8133)
Multinuclear Magnetic Resonance Spectroscopy
Principles of Nuclear Magnetic Resonance (NMR). The NMR parameters to be
studied are: chemical shift, spin-spin coupling,
electric quadruple coupling, spin-spin and spin-lattice relaxation rates. NMR and the
periodic table. Dynamic NMR. Applications in
chemistry and biochemistry. The Fourier Transform technique. Pulse sequences. Basic
principles and applications of two-dimensional NMR.
Chemistry 65.529 (CHM8154)
Reaction Intermediates
Introduction to the basic principles of photo-chemistry in condensed phases as a
method for the generation of reactive
intermediates. This is followed by a series of selected
topics to cover various types of reaction
intermediates and the techniques for their study.
Topics include: excited states, free radicals,
carbenes, biradicals, enols, carbocations and
zwitterionic intermediates. The techniques include
laser and conventional flash photolysis, pulse radiolysis, esr, CIDNP and matrix
isolation. Several of these topics are covered in
student seminars.
Chemistry 65.530 (CHM8159)
Total Synthesis: Strategies and Case Studies
General procedures for the total synthesis of natural products will be examined. A
general discussion of retrosynthetic planning,
choice of starting materials, multiple bond
construction, stereochemical considerations and
choice of strategies will be followed by the
analysis of recent syntheses. Comparison of
alternative solutions emanating from different
laboratories will be studied as will recent trends including pericyclic reactions, free
radical cyclizations, etc. A reasonable knowledge
of modern organic reactions is assumed.
Chemistry 65.531 (CHM8160)
Chiron Approach to Natural Product
Syntheses
Retrosynthetic analysis and description of natural product total synthesis through
the chiron strategy with emphasis on carbohydrates and amino acids as chiral
building blocks. Macrolides and polyether
synthesis. Diversity in carbohydrates; chiral
templates and their selective manipulations. Aspects
of protecting group chemistry, stereoelectronic effects, and chirality induction and transfer.
Chemistry 65.532 (CHM8132)
Enzymology and Protein Chemistry
Basic principles of structure-function relationships in proteins. Chemical nature
of polypeptides and the folded conformation of proteins. Enzymatic catalysis; protein
engineering.
Chemistry 65.533 (CHM8126)
Bioorganic Chemistry
Overview of recent developments in the general area of biocatalysis. Current examples
of the biotransformation of organic compounds using enzyme models, abzymes,
enzymes, immobilized enzymes, microbial cells and recombinant microbial cells.
Biosynthetic procedures of industrial importance in
waste management.
Chemistry 65.537 (CHM8169)
Chemistry of the Transition Metals
Introduction. Bonding in transition metal complexes: V.B. treatment, crystal field and
ligand field, Jahn-Teller effect, spectrochemical
series. Nomenclature. M-M bonds between transition metals. General introduction,
bonding, treatment of zerovalent clusters, treatment
of medium valent clusters. Descriptive chemistry. Activation of small molecules (CO,
N2, CO2, NO). Activation of H2 and of C-H, agostic interactions. Theoretical
background. Descriptive chemistry. Olefin activation.
Theoretical background, metathesis,
polymerization, isomerization, carbonylation, insertion
reactions. Environmental catalysis.
Chemistry 65.538 (CHM8122)
Solid State Chemistry
Thermodynamic and kinetic aspects of solid state synthesis. Spectroscopic and
structural characterization of solids. Chemical and
physical properties of solids including intercalation reactions, ionic conductors, glasses,
electronic, magnetic, optical, and physical/mechanical properties.
Precludes additional credit for Chemistry 65.545 (CHM8127) (if taken before 1996-97).
Chemistry 65.539 (CHM8144)
Electron Transfer Reactions: Theory and Experiment
Development of electron transfer theory from classical, semi-classical to quantum
mechanical treatments. Recent experimental results related to classical Marcus electron
transfer theory and the application of electron
transfer theory to biological processes.
Chemistry 65.540 (CHM8114)
Special Topics in Non-Metal Chemistry
Topics of current interest in non-metal chemistry. The content of this course may
vary from year to year.
Chemistry 65.541 (CHM8117)
Organometallic Chemistry
A discussion of the formation, character, bonding and reactions of compounds
containing organic ligands bound to metals through
from one to eight carbon atoms. Industrial processes (olefin meta-thesis, the OXO
process, the Monsanto acetic process, etc.) and
biological processes (e.g. reactions catalyzed by coenzyme B12) are also examined. The
emphasis is on transition metal chemistry, including synthesis and mechanisms of the
reactions concerned, and on the physical techniques available for characterization of
the compounds.
Chemistry 65.542 (CHM8115)
Special Topics in Inorganic Chemistry
Topics of current interest in inorganic chemistry. In the past, the course has covered
Ceramics: binary and ternary phase diagrams and their thermodynamic basis;
pyrometallurgical and ceramic thermochemistry; glasses;
molten salts and solid solutions; defects; doping and preparation of pure materials;
electrical and surface properties of ceramics.
Chemistry 65.543 (CHM8112)
Methods in Analytical Chemistry
This course describes the criteria used in choosing the best analytical technique for
specific problems including accuracy, precision, sensitivity, linearity, detection limits,
interferences and the commercial availability of
suitable instrumentation for analysis by atomic spectroscopy, electro-chemistry, chromatog
raphy, molecular spectrometry and mass spectrometry.
Chemistry 65.544 (CHM8125)
Organic Synthesis (Carbanion Chemistry)
Discussion of recent developments in the use of carbanion chemistry for the making
of carbon-carbon and carbon-heteroatom bonds. Particular emphasis is given to methods
which yield optically active products. In the most recent course the following topics were
covered: methods of generating carbanions, kinetic versus thermo-dynamic
acidity, heteroatom-stabilized carbanions, the aldol
and related condensations, Michael addition reactions, and ortho-metalation in aromatic
systems.
Chemistry 65.545 (CHM8166)
Advanced Carbohydrate Chemistry
Medicinal organic chemistry related to carbohydrates. New glycosylation strategies in
the design of O, C, N, S and P-glycosyle derivatives. Nucleotides and glycopeptides
synthesis. Glycoconjugate synthesis and their immunochemical significance as
vaccines, diagnostics and cell targeting systems. Glycopolymer preparations. Biological
roles of carbohydrates.
Chemistry 65.546 (CHM8164)
Organic Polymer Chemistry
Introduction to basic principles of polymer chemistry, industrial and synthetic
polymers, different types of polymerization and
polymer characterization. This is followed by a series of selected topics to cover some
important polymers with emphasis on the synthesis, such as commodity plastics,
engineering thermoplastics and specialty polymers. Also offered at the undergraduate level,
with different requirements, as Chemistry 65.424, for which additional credit is precluded.
Prerequisites: Chemistry 65.321 and 65.322 and/or 65.423 or the equivalent. Students
should have a basic knowledge of organic reaction mechanisms and stereochemistry.
Chemistry 65.547 (CHM8134)
Spectroscopy for Organic Chemists
Analysis of proton NMR spectra. Fourier transform 13C NMR, strategies for structure
elucidation relaxation times, two-dimensional NMR. Aspects of mass spectrometry. Also offered
at the undergraduate level, with different requirements, as Chemistry 65.442, for which
additional credit is precluded.
Chemistry 65.548 (CHM8122)
Special Topics in Organic Chemistry
Topics of current interest in organic chemistry. In the past, one course has covered
solid state NMR: chemical aspects of solid state
structure; molecular ordering and motion in the
solid state; magnetic interactions; hydrogen, deuterium and 13C NMR; experimental
methods; applications; relationship between high resolution solid-state and solution NMR.
Chemistry 65.549 (CHM8123)
Recent Advances in Organic Chemistry
Topics of current interest will be discussed.
Chemistry 65.550 (CHM8116)
Analytical Instrumentation
Principles of modern electronic instrumentation and their application in the
chemical laboratory. Scientific instruments;
measurement and control systems; microcomputer interfacing. Instrumentation concepts
including feedback control, signal-to-noise
enhancement, data acquisition, and signal
processing will be presented along with the
techniques and devices for their implementation. A
parallel laboratory is taught using modern test instruments. Examples include
absorption spectrophotometer, derivative titration
thermocouple, pH meter, and cyclic voltammetry.
Chemistry 65.551 (CHM8220)
Problems in Organic Chemistry
The problems which are assigned in this course are of two types: (1) written
examinations on a particular topic in organic
chemistry, (2) critical reviews of papers in the
current organic literature, i.e. a simulated referee's
report on the paper. In order to pass the course, eight problems must be solved satisfactorily.
Chemistry 65.552 (CHM8110)
Analytical Approach to Chemical Problems
Case-study approach to a variety of problems in agricultural, biochemical,
environmental, food processing, geological, industrial
and surface sciences that can be solved by analytical chemistry. Comparative study of
analytical methods appropriate to each case
includes: capillary electrophoresis,
chemiluminescence, electrochemical biosensors, Fourier
transform infrared spectroscopy, inductively
coupled plasma emission, neutron activation
analysis, sensor arrays, secondary ion mass
spectrometry, tandem mass spectrometry, and ultra-high
resolution nuclear magnetic resonance spectroscopy. Modern data analysis
techniques such as pattern recognition are also discussed.
Chemistry 65.553 (CHM8108)
Analytical Mass Spectrometry
The course consists of four sections: the basics of mass spectrometry and gas phase
ion chemistry; the instrumentation currently available and the principles of its operation,
methods of ionization; separation techniques,
their successes and limitations when connected to a mass spectrometer; and the obtaining and
interpretation of data. The relationships between mass spectra and chemical
structure are also examined.
Chemistry 65.555 (CHM8119)
Advanced Ultratrace Analytical Chemistry
Criteria for evaluation and selection of analytical techniques and methods.
Simultaneous and sequential multielement analysis.
Atomic absorption, atomic emission and atomic fluorescence spectrometry, using
optical spectrometric and mass-spectrometric determination. Electroanalytical techniques.
Applications of these techniques at trace and ultratrace levels in complex matrices.
Chemistry 65.556 (CHM8120)
Environmental Analytical Chemistry of Inorganic Systems
Sampling of the atmospheric and the aquatic environment. The problems of sampling
artifacts and of blanks in the sub-parts-per-trillion concentration levels. Analytical
techniques and methods for quantitative
determination of analytes in elemental and isotopic
form. Analytes in molecular form and analytical
techniques for chemical speciation. Advantages and limitations of various speciation schemes.
Chemistry 65.557 (CHM8162)
Environmental Organic Chemistry
Methods for determination of organic analytes in environmental systems. All aspects of
a method will be discussed, including sampling, sample treatment, measurement, quality
control, and data significance. Application to
such environmentally important analytes as PCGs, dioxins, pesticides, herbicides,
trihalo- methanes, and polycyclic aromatic
hydrocarbons. Rationale and selection of specific
methods.
Chemistry 65.558 (CHM8163)
Special Topics in Analytical Chemistry
Topics of current interest in analytical chemistry. The content of this course may
change from year to year.
Chemistry 65.570 (CHM8143)
Special Topics in Physical Chemistry
Topics of current interest in physical chemistry. The content of this course may
change from year to year.
Chemistry 65.571 (CHM8145)
Photochemistry
Photochemical reactions of small molecules and the relation to atmospheric
chemistry. Lasers and applications to measurements
of the dynamics of elementary reactions. Production and detection of reactive
species. Energy transfer processes. Photolysis of
formaldehyde and carbonyl compounds.
Multiphoton absorption of infrared radiation.
Chemistry 65.572 (CHM8135)
Theories of Chemical Reaction Rates
Concepts and theories of chemical kinetics. Significance of activation energy;
transition state theory and more modern
developments; reaction dynamics. Other optional topics
include unimolecular gas reactions, theory of solvent effects, homogeneous and
heterogeneous catalysis, and kinetic isotope effects.
Chemistry 65.573 (CHM8137)
Advanced Chemical Kinetics
Study of the principles involving the exchange of translational, rotational, vibrational and
electronic energy in molecular collisions. Influence of energy transfer processes on
thermal unimolecular and biomolecular reactions. Study of the relationship between
microscopic and macroscopic kinetics of elementary reactions.
Chemistry 65.574 (CHM8142)
Symmetry in Chemistry
Introduction to group theory with emphasis upon irreducible representations.
Application to molecular vibrations, molecular
orbital theory and transition metal chemistry.
Chemistry 65.576 (CHM8148)
Gas Phase Ion Chemistry
Structure, energetics and reaction kinetics of ions in the gas phase. Small organic ions,
chemistry of free radicals, hypervalent species. Contemporary experimental methods in
the physical chemistry of fast ion beams. Emphasis will also be upon recent work on
novel ions and neutral species of relevance to
interstellar chemistry.
Chemistry 65.577 (CHM8138)
Enzyme Kinetics and Mechanism
Kinetic studies of enzymic reactions. Enzyme efficiency, specificity and versatility.
Mechanisms and regulation of enzymic reactions. Analyses of enzymic systems.
Chemistry 65.578 (CHM8156)
Principles of Toxicology
This course identifies the basic theorems of toxicology with examples of current
research problems. Toxic risk is defined as the
product of intensive hazard and research problems. Each factor is assessed in scientific
and social contexts and illustrated with many
types of experimental material.(Also listed as
Biology 61.642(BIO9101))
Chemistry 65.579 (CHM8157)
Chemical Toxicology
An introduction to modeling chemical hazards and exposures at the cellular level.
The properties of toxic substances are compared to the responses of enzymatic systems.
These interactions are defined as Quantitative Struc
ture-Activity Relationships and used to interpret hazardous materials under regulations
such as WHMIS. (Also listed as Biology 61.579(BIO8113))
Prerequisite: Biology 61.642/Chemistry 65.578 (BIO9101/CHM8156).
Chemistry 65.581 (CHM8256S)
Seminar I
Chemistry 65.582 (CHM8257S)
Seminar II
Chemistry 65.585 (CHM8167)
Seminar in Toxicology
This course introduces the seminar format and involves student, faculty and invited
seminar speakers. The student will present a seminar and submit a report on a current topic
in toxicology. (Also listed as Biology 61.645)
Chemistry 65.590 (CHM8158)
Directed Special Studies
Under unusual circumstances and with the recommendation of the research
supervisor, it is possible to engage in directed study on
a topic of particular value to the student. This may also be used for credit if there are
insufficient course offerings in a particular
field of chemistry.
Chemistry 65.599 (CHM7999)
M.Sc. Thesis
Chemistry 65.699 (CHM9999)
Ph.D. Thesis
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