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Graduate Calendar Archives: 2001 / 2002

Ottawa-Carleton Institute of Biology

Herzberg Building 2240
Telephone: (613) 520-2600 ext. 8769
Fax: (613) 520-5613

The Institute

Director of the Institute, N. Chaly
Associate Director, G. Drouin

Students pursuing studies in biological sciences at the M.Sc. and Ph.D. levels in the Ottawa area do so in a co-operative program that combines the resources of the Departments of Biology of Carleton University and the University of Ottawa. The two universities have a joint committee supervising the programs, regulations, and student admissions.

Students are admitted for graduate work under the general regulations of the Institute. Additional criteria for admission include academic performance, research experience, and referees' appraisals. The student must also be accepted by a faculty member who will supervise the research project, and the choice of supervisor will determine the primary campus location of the student. The student's advisory committee will normally include faculty members from both universities.

Requests for information, and completed applications should be sent to the Director or Associate Director of the Institute.Additional information may also be obtained through the Institute website, at www.carleton.ca/~jhelava/biology/biology.html

Members of the Institute

  • J.B. Armstrong, Developmental Biology
  • J.T. Arnason, Biochemical Ecology
  • J.M. Blais, Bio-geochemistry of Toxic Substances
  • Linda Bonen, Molecular Biology
  • C. Boutin, Agro-ecosystems, plant conservation, wildlife habitat, herbicides, biodiversity
  • Stephen J. Brooks, Animal Biochemistry
  • D.L. Brown, Cell Biology
  • M.J. Canny, Whole Plant Physiology
  • N. Cappuccino, Population and Community Ecology
  • G.R. Carmody, Population Genetics
  • P.M. Catling, Plant Biosystematics
  • N.Chaly, Cell Biology
  • François Chapleau, Fish Evolution
  • Christiane Charest, Plant Physiology
  • J.J. Cheetham, Membrane Biochemistry
  • D.J. Currie, ,Macroecology, Biogeography
  • J.R. Dillon, Molecular Genetics
  • Guy Drouin, Molecular Genetics
  • Lenore Fahrig, Population Ecology and Ecological Modelling
  • J.M. Farber, Food Microbiology
  • J.C. Fenwick, Comparative Endocrinology
  • C.S. Findlay, Evolution
  • Mark Forbes, Evolutionary Ecology
  • R.M. Fourney, DNA Forensics
  • Kathryn Freemark, Ecology, Behaviour and Systematics
  • A.J. Gaston, Conservation Biology
  • K.M. Gilmour, Comparative Respiratory Physiology
  • L. Gillespie, Systematics and Evolution of Flowering Plants
  • W.D. Gould, Biotechnology
  • D.A. Hickey, Genetics and Bioinformatics
  • J.G. Houseman, Insect Physiology
  • Byron Johnson, Cell Biochemistry
  • D.A. Johnson, Molecular Biology
  • Sean W. Kennedy, Environmental Toxicology
  • Iain Lambert, Molecular Biology and Genetic Toxicology
  • D.R.S. Lean, Ecotoxicology
  • C. Martin, Development Genetics
  • M.E. McCully, Plant Ultrastructure and Development
  • B.L.A. Miki, Plant Molecular Biology
  • Pierre Mineau, Ecotoxicology
  • R.E.J. Mitchel, Radiobiology
  • T.W. Moon, Comparative Physiology and Biochemistry
  • Antoine Morin, Freshwater Ecology
  • Micheline Paulin-Levasseur, Cell Biology
  • S.B. Peck, Arthropod and Beetle Evolution Systematics
  • S.F. Perry, Comparative Respiratory Physiology
  • Bernard Philogène, Ecophysiology of Insects, Chemical Ecology
  • Frances Pick, Aquatic Ecology
  • Jaroslav Picman, Behavioural Ecology
  • S. Regan, Plant Molecular Biology and Genomics
  • C.B. Renaud, Fish Biology
  • V.L. Seligy, Molecular Genetics
  • Andrew Simons, Plant life-history evolution
  • John Sinclair, Biophysics of Cells
  • Myron Smith, Fungal Molecular Genetics
  • K.B. Storey, Biochemical Adaptations
  • Vance Trudeau, Comparative Endocrinology
  • J.P. Vierula, Molecular Biology
  • P.R. Walker, Molecular Mechanisms of Apoptosis
  • P.J. Weatherhead, Behavioural Ecology
  • Jean-Michel Weber, Metabolic Physiology
  • R.C. Wyndham, Microbial Genetics and Ecology
  • Hiroshi Yamazaki, Bacterial Metabolism, Biotechnology

    Ottawa-Carleton Specialization in Behavioural Neuroscience

    The Departments of Biology and Psychology at Carleton University, and the School of Psychology at the University of Ottawa provide a graduate specialization in behavioural neuroscience at the M.Sc. and Ph.D. level. For further details see p.263.

    Ottawa-Carleton Collaborative Program in Chemical and Environmental Toxicology

    The Departments of Biology and Chemistry at Carleton University and at the University of Ottawa provide a collaborative program in chemical and environmental toxicology at the M.Sc. level. For further details see p. 112.

    Each campus is well equipped for a wide range of biological research. Some major equipment and facilities include scanning and transmission electron microscopes; confocal laser scanning microscope; digital light microscope and image analysis facilities; conventional and digital darkrooms; animal and plant growth facilities; animal cell culture facilities; electro-physiology equipment; computer systems for genomic studies, modelling of ecological systems, and access to the Internet and the Web; DNA and protein analysis facilities, including electrophoresis and chromatographic equipment, and ultra-centrifuges. Students also benefit from the resources of nearby government laboratories and libraries, including Agriculture Canada, Environment Canada, Health and Welfare Canada, and the National Research Council.

    Master of Science

    Admission Requirements

    An Honours B.Sc. or equivalent degree at a standard acceptable to the two universities is required for admission to the M.Sc. program. Applicants with acceptable standing in a non-honours degree may be admitted to a qualifying-year program which will be determined in each case by the admissions committee.

    Applicants must demonstrate a fluent knowledge of English (Carleton), or either English or French (Ottawa).

    Program Requirements

    The M.Sc. degree will be conferred upon a candidate who has fulfilled the following requirements:

    * Completion of the advanced courses specified by the admissions committee and the student's advisory committee; these will range from one to three full (two-term) courses, depending on the background and research program of the student. At least one course at the graduate level must be included, and not more than one course at the Fourth-year honours level (completed while registered as a graduate student) may form part of the candidate's course requirements. The passing grade for all required courses is 70% or the equivalent, and the student is not allowed a supplemental examination. Directed studies or reading courses may not make up more than half of the required number of courses. The admissions committee or the student's advisory committee may also direct the student to take or to audit additional courses. Knowledge of a second language may be specified as a requirement.

    * Completion of at least two terms as a full-time student resident at one of the two universities is normally required. Programs for part-time students may be arranged.

    * Presentation of one public seminar on the candidate's thesis research

    * Completion of a thesis incorporating the results of original research carried out under the direct supervision of an approved faculty member

    * Successful oral defence of the thesis before an examination board of at least three faculty members, normally drawn from both universities.

    Guidelines for Completion of Master's Degree

    The maximum time limits for the completion of the requirements of the master's program are listed in this Calendar in the General Regulations, Section 13 (see p.65.) Full-time candidates in the master's program are expected to complete their degree requirements within six terms of first registration for full-time study. Part-time candidates in the master's program, and candidates who elect to complete their program by a combination of full-time and part-time study, are expected to complete their degree requirements within four calendar years or twelve terms from the initial registration in the master's program.

    Doctor of Philosophy

    Admission Requirements

    An M.Sc. from a recognized university is usually required for entry to the Ph.D. program; however, an applicant with a first class B.Sc. and excellent references may be admitted directly to the Ph.D. program. A student already registered for the M.Sc. may be permitted to transfer to the Ph.D. program following a recommendation by the departmental graduate committee and successful completion of the Qualifying Examination required of Ph.D. candidates.

    All applicants must demonstrate a fluent knowledge of English (Carleton), or either English or French (Ottawa).

    Program Requirements

    The Ph.D. degree will be conferred upon a candidate who has fulfilled the following requirements:

    * Completion of the courses at the graduate level specified by the admissions and advisory committees; these will range from one to four full courses (two to six courses if admitted without an M.Sc.), depending on the background and research program of the student. Only graduate courses may form part of the candidate's course requirements. The passing grade for all required courses is 70%, and the student is not allowed a supplemental examination. Directed studies or reading courses may not make up more than half of the required number of courses. The admissions committee or the student's advisory committee may also direct the student to take or to audit additional courses. Knowledge of a second language may be specified as a requirement.

    * Completion of an oral Qualifying Examination within approximately twelve months of entry into the program; this examination will cover the candidate's area of research, and related topics. The format of the examination will be established by the departmental graduate committee and approved by the admissions committee. The examination committee will generally be composed of faculty members of both universities.

    * Presentation of at least one public seminar on the candidate's thesis research.

    * A thesis incorporating the results of original research carried out under the direct supervision of an approved faculty member

    * Completion of at least four terms as a full-time student resident at one of the two universities (or six terms if admitted without an M.Sc.) is normally required. Under exceptional conditions programs may be arranged for part-time students.

    * Successful oral defence of the thesis before an examination board of at least five faculty members, with representation from both universities, and including an external examiner from outside the two universities who is an authority on the thesis research area.

    Guidelines for Completion of the Doctoral Degree

    The maximum time limits for the completion of the program requirements of the doctoral program are listed in the General Regulations, Section 13. Full-time candidates in the doctoral program are expected to complete their oral Qualifying Examination within approximately twelve months of entry into the program. Part-time candidates in the doctoral program are expected to complete their oral Qualifying Examination within approximately eighteen months of entry into the program. Full-time candidates are expected to complete their degree requirements within four calendar years or twelve terms of registered full-time study. Doctoral candidates who have transferred from the master's to the doctoral program without completing the master's program are expected to complete their degree requirements within four calendar years or twelve terms of registered full-time study from initial registration in the master's program. Part-time candidates in the doctoral program, and candidates who elect to complete their program by a combination of full- and part-time study, are expected to complete their degree requirements within six calendar years or eighteen terms after the date of initial registration.

    Graduate Courses

    Not all of the following courses are offered in a given year. For an up-to-date statement of course offerings for 2001-2002, please consult the Registration Instructions and Class Schedule booklet published in the summer.

    F,W,S indicates term of offering. Courses offered in the fall and winter are followed by T. The number following the letter indicates the credit weight of the course: 1 denotes 0.5 credit, 2 denotes 1.0 credit, etc.

    Biology 61.501F1 (BIO5101)
    Topics in Biotechnology
    A course concerned with the utilization of biological substances and activities of cells, genes, and enzymes in manufacturing, agricultural, and service industries. A different topic will be selected each year.

    Prerequisite:
    A course in cell physiology or biochemistry, or permission of instructor.
    Biology 61.503F1 (BIO5103)
    Comparative Biochemistry
    Advanced topics emphasizing biochemical structures, functions, and methodologies in the context of animal (invertebrates and vertebrates) adaptations to environmental stress. The course will be offered in alternate years.

    Prerequisite:
    An undergraduate biochemistry course.
    Biology 61.509F1, W1 (BIO8124)
    Ontario Vegetation: Patterns, Processes and Protection
    Patterns of vegetation and plant species distributions in Ontario will be investigated with respect to their origin and maintaining processes. Current methods of protection of significant and representative vegetation using zonal concepts will be considered.
    Biology 61.510F1 or W1 (BIO5301)
    Plant Development
    An advanced course dealing with selected topics in the experimental study of plant development.
    Biology 61.515F1 (BIO5302)
    Methods in Molecular Genetics
    The purpose of this course is to review the fundamental theory and techniques in genetic manipulation of prokaryotes and eukaryotes and to examine some of the innovative new strategies being applied to a variety of problems in molecular biology.
    Precludes additional credit for Biology 61.416 or 61.517.

    Prerequisite:
    Graduate standing and permission of the Department.˙
    Biology 61.516W1 (BIO5308)
    Laboratory Techniques in Molecular Genetics
    This laboratory course, which is complementary to Biology 61.515, is designed to give students practical experience in many of the important techniques in molecular genetics.
    Precludes additional credit for Biology 61.419 or 61.517.

    Prerequisite:
    Graduate standing and permission of the Department.
    Biology 61.521F1 (BIO8301)
    Evolutionary Genetics and Computer˙ Analyses
    Students will learn the basic concepts in molecular evolution and gain hands-on experience with the computer analysis of DNA sequences.Topics covered will include molecular sequence databases, multiple alignments, amino acid and codon usage, molecular clocks, and phylogenetic trees.

    Prerequisites:
    Graduate standing plus basic courses in genetics and evolution; permission of the Department.
    Biology 61.522F1 or W1 (BIO8302)
    Topics in Evolutionary Genetics
    A lecture/seminar course on the genetic mechanisms and forces responsible for variation and evolutionary change in natural pop-ulations.Topics to include protein and genome evolution, molecular phylogenies, DNA sequences in population biology, and the evolution of multigene families.

    Prerequisites:
    Graduate standing plus basic courses in genetics and evolution; permission of the Department (Alternate years)
    Biology 61.523F1 (BIO8303)
    Techniques of Light Microscopy
    An advanced laboratory and lecture course on the principles and techniques of light microscopy.
    Precludes additional credit for Biology 61.520 (BIO8238) (if taken before 1997-98).

    Prerequisite:
    Open to Fourth-year and graduate students with consent of the instructor.
    Biology 61.524W1 (BIO8304)
    Techniques of Electron Microscopy
    An advanced laboratory and lecture course on the principles and techniques of electron microscopy.
    Precludes additional credit for Biology 61.520 (BIO8238) (if taken before 1997-98).

    Prerequisite:
    Open to Fourth-year and graduate students with permission of the instructor.
    Biology 61.525T2 (BIO5204)
    Plant Physiology and Metabolism
    An advanced course dealing with selected topics in plant physiology and plant metabolism.

    Prerequisite:
    Graduate standing or permission of the Department.
    Biology 61.534T2 (PSY6201)
    Basics of Neuroscience
    A comprehensive neuroscience course from cellular levels to neural systems and behaviour. Topics covered include aspects of neuroanatomy, neurophysiology, neuropharmacology and behavioural and cognitive neuroscience. (Also listed as Psychology 49.520)
    Biology 61.536F1, W1 (BIO9201)
    Photobiology
    A course dealing with the interaction between light and living organisms, including an introduction to photochemistry, and a detailed study of photosynthesis, vision, photosensitivity, and photoperiodism.

    Prerequisite:
    An advanced course in animal or plant physiology or biochemistry, or permission of the Department.
    Biology 61.537F1 or W1 (BIO8122)
    Advanced Insect Physiology
    Physiological characteristics of insects.
    Biology 61.542T1 (BIO8162)
    Developmental Endocrinology/Topics in Comparative Endocrinology
    A lecture and reading course concerned with classical as well as current topics in the field of comparative endocrinology. Special emphasis is placed on the vertebrates. Offered in alternate years.

    Prerequisite:
    An undergraduate course in endocrinology.
    Biology 61.545T2 (BIO9202)
    Project in Applied Ecology
    A course in the form of a special research project in which the student identifies an environmental problem and the corporate or governmental body that has the power to rectify the problem. (Enrollment is limited).
    Biology 61.546F1 or W1 (BIO9303)
    Advanced Plant Ecology
    Plant population biology, and its usefulness in explaining attributes of plant communities is discussed. During the labs, projects will be carried out to clarify topics such as vegetation classification and competition.
    Biology 61.547F1 or W1 (BIO5305)
    Quantitative Ecology
    A course on analysis of the distribution and abundance of organisms, and of related environmental phenomena.

    Prerequisites:
    Graduate standing, courses in elementary ecology, elementary statistics and biostatistics, and permission of the Department.
    Biology 61.549F1,W1 (BIO5306)
    Mathematical Modelling for Biologists
    This course is designed to develop mathematical tools for the modelling of biological processes. The student is taught the necessary mathematics and a computer language, and guidance is given in the choice of simulation of a biological process.
    Biology 61.550T2 (BIO5207)
    Selected Topics
    Courses in selected aspects of specialized biological subjects not covered by other graduate courses; course details will be available at registration.
    Biology 61.551F1 (BIO8100)
    Selected Topics in Biology I
    Courses in selected aspects of specialized biological subjects not covered by other graduate courses; course details will be available at registration.
    Biology 61.552W1, S1 (BIO8102)
    Selected Topics in Biology II
    Courses in selected aspects of specialized biological subjects not covered by other graduate courses; course details will be available at registration.
    Biology 61.553T1 (BIO5901)
    Recent Advances in Biology
    A course intended for all first-year graduate students to bring them up to date in the various major areas of biology. The course consists of selected readings, lectures, and invited speakers. The course is graded Satisfactory/Unsatisfactory.
    Biology 61.556F1,W1(BIO5213)
    Advanced Insect/Animal Systematics
    A lecture and seminar course concerning methods, roles and advances in systematics of insects and other animals. One research project required.

    Prerequisite:
    A 400-level course in identification or classification of insects or other animals.
    Biology 61.558F1 (BIO8306)
    Advanced Topics in Ecology I
    Lectures, seminars and discussions on current literature on experimental approaches, concepts, and findings in population and community ecology, ecosystem and landscape ecology, and biostatistics. The content complements 61.559 (BIO8307).
    Precludes additional credit for Biology 61.548 (BIO9200) (if taken before 1997-98).
    Biology 61.559W1 (BIO8307)
    Advanced Topics in Ecology II
    Lectures, seminars and discussions on current literature on experimental approaches, concepts and findings in population and community ecology, ecosystem and landscape ecology and biostatistics. The content complements 61.558 (BIO8306).
    Precludes additional credit for Biology 61.548 (BIO9200) (if taken before 1997-98).
    Biology 61.561F1 (BIO5161)
    Advanced Topics in Insect Evolution
    An exploration of major concepts and questions in insect evolution in the areas of systematics, morphology, the fossil record, biology, and behaviour.The content complements 61.562W1 (BIO5162).
    Precludes additional credit for Biology 61.560T2 (BIO5160).
    Biology 61.562W1 (BIO5162)
    Advanced Topics in Insect Evolution
    An exploration of major concepts and questions in insect evolution in the areas of systematics, morphology, the fossil record, biology, and behaviour. The content complements 61.561F1 (BIO5161).
    Precludes additional credit for Biology 61.560T2 (BIO5160).
    Biology 61.565F1, W1, S1 (BIO5102)
    Field Course
    Credit for this 0.5 credit course is based on a total of three weeks of field-course modules, involving one or two weeks of intensive and continuous field work with attendant assignments. For details, see coordinator.
    Biology 61.579 (BIO 8113)
    Chemical Toxicology
    An introduction to modeling chemical hazards and exposures at the cellular level. The properties of toxic substances are compared to the responses of enzymatic systems. These interactions are defined as Quantitative Structure-Activity Relationships and used to interpret hazardous materials under regulations such as WHMIS. (Also listed as Chemistry 65.579(CHM 8157))

    Prerequisite:
    Biology 61.642/Chemistry 65.578(BIO 9101/CHM 8156).
    Biology 61.581F1 or W1 (BIO5105)
    Animal Behaviour
    A 0.5 credit course in animal behaviour from an ecological and evolutionary point of view, with additional independent assignments.

    Prerequisites:
    Biology 61.335 and 61.361 or equivalents and registration in a graduate program, or written permission of the Department.
    Biology 61.582F1 or W1 (BIO8365)
    Advanced Behavioural Ecology I
    Recent ideas and research on advanced topics dealing with the evolution of foraging, temporal, spatial, and reproductive strategies are discussed and critically examined. Offered in alternate years.
    Biology 61.599F, W, S
    M.Sc. Thesis
    Biology 61.601F1 (BIO8109)
    Advanced Molecular Biology I
    Recent advances in molecular biology. Topics for discussion may include: DNA structure and function, the organization of the genome; DNA, RNA and protein synthesis; the regulation of gene expression in eucaryotes and procaryotes. Normally offered in alternate years.
    Biology 61.602W1 (BIO8116)
    Advanced Molecular Biology II
    Recent advances in molecular biology. Topics for discussion may include: mutagenesis and DNA repair; molecular aspects of gene transfer; recombination and gene arrangement; molecular biology as applied to industrial and medical problems. Normally offered in alternate years.
    Biology 61.621F1 (BIO8117)
    Advanced Cell Biology I
    Recent advances in cell biology. Topics for discussion may include: the composition, biosynthesis, deployment three-dimensional organization and functions of the cytoskeleton, the cell-substrate attachment, cell motility, transport of organelles and axoplasmic transport, cell surface and extracelluar matrix. Normally offered in alternate years.
    Biology 61.622W1 (BIO8118)
    Advanced Cell Biology II
    Topics for discussion may include: the structure, composition and three-dimensional organization of the nucleus, mechanisms and regulation of genome replication, structure organization of transcription. , Nuclear reorganization during gamete development, fertilization, viral infection and the mitotic cell cycle. Normally offered in alternate years.
    Biology 61.623 F1,W1
    Special Topics in Neuroscience
    An in depth study of current topics in neuroscience. Course content varies yearly and has recently included cognitive neuroscience, neuropharmacology, neurodegeneration, behavioural medicine. (Also listed as Psychology 49.630)
    Biology 61.624F1,W1,S1 (ANA7400)
    Neuroscience Techniques
    Completion of a research project carried out under the supervision of a neuroscience faculty member. The student will learn a new neuroscience technique and apply it to a research objective. May be repeated for different projects. Students must obtain approval from the Director of the Neuroscience Specialization. (Also listed as Psychology 49.624)
    Biology 61.625F1 or W1 (BIO8319)
    Advanced Plant Physiology
    A lecture and seminar course dealing with selected topics in advanced plant physiology, available only to graduate students.

    Prerequisite:
    Biology 61.429 or equivalent, or permission of the Department.
    Biology 61.627F1 (BIO8164)
    Ion Channels
    A lecture and seminar course on the physiological and biophysical characteristics of ion channels. Topics are selected from such areas as: determinants of channel selectivity, conformation changes, gating, excitability methods of studying channels and cellular distribution, modulation and development of channels. Offered in alternate years.
    Biology 61.630F1 or W1 (BIO8320)
    Advanced Plant Biochemistry
    A lecture and seminar course, available only to graduate students, dealing with selected topics in advanced plant biochemistry.

    Prerequisites:
    Biology 61.425 and Biology 61.426/427, or permission of the Department.
    Biology 61.633T2
    Advanced Seminar in Neuroscience
    A seminar focussing on the active research areas and interests of faculty, guest lecturers and graduate students, as well as on current trends in diverse areas of neuroscience. (Also listed as Psychology 49.620)
    Biology 61.634F1 or W1 (BIO8361)
    Advanced Topics in Animal Physiology
    In-depth study of areas in animal physiology of current research interest.
    Biology 61.641F1 or W1(BIO8935)
    Recent Advances in Plant Biology
    Special topics of current interest.
    Biology 61.642 (BIO 9101)
    Principles of Toxicology
    This course identifies the basic theorems of toxicology with examples of current research problems. Toxic risk is defined as the product of intensive hazard and extensive exposure. Each factor is assessed in scientific and social contexts and illustrated with many types of experimental material.(Also listed as Chemistry 65.578(CHM 8156))
    Biology 61.643
    Ecotoxicology
    Concepts of ecotoxicology, emphasizing whole ecosystem response to hazardous contaminants. The focus is the impacts of chronic and acute exposure of ecosystems to toxicants, the methods of pesticide, herbicide and pollutant residue analysis and the concept of bound residues. (Also listed as Chemistry 65.575(CHM 9109))

    Prerequisite:
    Biology 61.642/Chemistry 65.578(BIO 9101/CHM 8156).
    Biology 61.644F1 or W1(BIO8938)
    Plant: Animal Interactions
    Secondary metabolites of plants and their role as attractants or antifeedants to animals and as allelopathic or antifungal agents. Emphasis is placed on co-evolution of plants and phytophagous organisms such as insects and mammals, and the ecological and physiological dimensions of this relationship. Offered in alternate years.
    Biology 61.645 (BIO 9105)
    Seminar in Toxicology
    This course introduces the seminar format and involves student, faculty and invited seminar speakers. The student will present a seminar and submit a report on a current topic in toxicology. (Also listed as Chemistry 65.585 CHM 8167))
    Biology 61.655F1 or W1 (BIO8108)
    Advanced Topics in Development
    Recent advances in developmental biology. Topics may include embryonic induction, regulation of morphogenesis and differentiation, mechanisms of regional specification and pattern formation, and developmental genetics. Offered in alternate years.
    Biology 61.680F1 or W1 (BIO8103)
    Advanced Behavioural Ecology II
    A seminar and laboratory course dealing with current topics in the study of animal behaviour.

    Prerequisites:
    Biology 61.581 or equivalent, or permission of the Department.
    Biology 61.699F, W, S
    Ph.D. Thesis
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